Thermo Fisher Scientific SIRP alpha Monoclonal Antibody (OX-41)
Rat SIRP alpha (CD172a) 인식 단일클론 항체로, Flow Cytometry, ICC/IF, RIA 등 다양한 분석에 적합. Unconjugated 형태이며, 1 mg/mL 농도로 제공. Protein G 정제 및 PBS 버퍼에 sodium azide 포함. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1 µg/1 million cells |
| Radioimmune Assays (RIA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OX-41 |
| Immunogen | Rat peritoneal macrophages |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1087294 |
Additional Formats
Product Specific Information
MA1-70021 detects SIRP in rat samples.
It has been successfully used in flow cytometry, immunocytochemistry, immunofluorescence, and radioimmunoassay procedures.
The immunogen is rat peritoneal macrophages.
Target Information
SIRP alpha (CD172a, signal-regulatory protein alpha) is a receptor-type transmembrane glycoprotein expressed on myeloid cells including granulocytes, dendritic cells (DCs), macrophages, mast cells, and hematopoietic stem cells.
It acts as a substrate for several activated tyrosine kinases (EGFR, PDGFR, src, insulin receptor) and negatively regulates receptor tyrosine kinase-coupled signaling pathways.
Binding of SIRP alpha to CD47 leads to phosphorylation of ITIMs and recruitment of SHP-1 and SHP-2 phosphatases.
This interaction inhibits macrophage phagocytosis and modulates T cell and DC activation.
SIRP alpha influences cellular responses to serum, growth factors, insulin, oncogenes, hormones, and adhesion, playing roles in physiological and pathological processes.
Cancer cells often overexpress CD47, activating SIRP alpha and preventing macrophage-mediated destruction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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