Thermo Fisher Scientific TCR alpha/beta Monoclonal Antibody (R73)

Thermo Fisher Scientific TCR alpha/beta Monoclonal Antibody (R73)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Store at 4°C; for long term storage, aliquot and freeze in single use volumes at -20°C, avoiding freeze-thaw cycles.

Target Information

The T cell antigen receptor (TCR) consists of a ligand-specific alpha/beta heterodimer associated with invariant CD3 subunits (gamma, delta, eta, and zeta). These are essential for surface expression and signal transduction. Activation through TCR induces differentiation, proliferation, and cytokine production.
Most T cells in blood and lymphoid organs express TCR alpha/beta, while gamma/delta T cells are mainly found in epithelial tissues and infection sites.
The TCR-CD3 complex formation in the endoplasmic reticulum is critical for functional expression; absence of any chain halts surface expression.
TCR recognition of self-peptides is linked to autoimmune diseases and tumors. Superantigen engagement can lead to toxic shock syndrome. Autoantibodies against TCR Vβ segments have been found in RA and SLE patients, potentially modulating immune responses.
Human T cells typically express TCR alpha-beta with CD4 or CD8 (single positive). Increased alpha-beta double-negative T cells are observed in autoimmune and immunodeficiency disorders. Gamma-delta T cells, found in epithelial tissues, exhibit less diversity and distinct antigen recognition, with subsets showing antitumor and immunoregulatory functions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.