Thermo Fisher Scientific Cortactin Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Purity is >95% by SDS-PAGE.

Target Information

Cortactin (Cttn) is a ubiquitous actin-binding protein originally identified as a substrate for Src. It contributes to actin cytoskeleton organization and cell shape, and plays a role in lamellipodia formation and cell migration. Cortactin accumulates in peripheral, actin-enriched structures, facilitating actin network formation. It contains four major domains: N-terminal acidic (NTA), tandem repeats, C-terminal proline-rich, and SH3 domains. The NTA domain associates with the Arp2/3 and WASP complex at F-actin branches. Cortactin promotes cell motility and invasion, including a critical role in invadopodia formation, which are actin-rich protrusions involved in ECM degradation by cancer cells. It is phosphorylated by Src family kinases at Y421, Y466, and Y482, and by Erk family kinases at S405 and S418.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.