Thermo Fisher Scientific Cortactin Polyclonal Antibody
Cortactin 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC 등 다양한 응용에 적합. 인간, 마우스, 랫트 반응성. 고순도(>95%) 항원 친화 크로마토그래피 정제. 액상 형태, 1 mg/mL 농도, 장기 보관 시 -20°C 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–200 of human Cortactin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803383 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
Cortactin (Cttn) is a ubiquitous actin-binding protein originally identified as a substrate for Src. It contributes to the organization of the actin cytoskeleton and cell shape, playing a key role in lamellipodia formation and cell migration. Cortactin accumulates in peripheral, actin-enriched structures, facilitating actin network formation.
It has four major domains of interest: the N-terminal acidic (NTA), tandem repeats, C-terminal proline-rich, and SH3 domains. NTA associates with the Arp2/3 and WASP complex at F-actin branches.
Cortactin is involved in promoting cell motility and invasion, including a critical role in invadopodia—actin-rich subcellular protrusions associated with ECM degradation by cancer cells.
Phosphorylation occurs at Y421, Y466, and Y482 by Src family kinases, and at S405 and S418 by Erk family kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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