Thermo Fisher Scientific ACD Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  TLEGPCTAPPV THWAASRCKA TGEAVYTVPS SMLCISENDQ LILSSLGPCQ RTQGPELPPP DPALQDLSLT LIASPPSSPS
• Highest antigen sequence identity to orthologs:
  Mouse 37%, Rat 48%

Target Information

This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway.

• The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase, converting orotic acid to orotidine-5'-monophosphate.
• The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase, converting orotidine-5'-monophosphate to uridine monophosphate.
  Defects in this gene cause hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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