Thermo Fisher Scientific SNAI2 Monoclonal Antibody (OTI2E3), TrueMAB
SNAI2(Slug) 단백질을 인식하는 Mouse monoclonal antibody로 Western blot에 최적화됨. Human 시료 반응성. Lyophilized 형태로 제공되며, 재구성 시 1 mg/mL 농도 권장. PBS 및 trehalose buffer로 안정화되어 장기 보관 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2E3 |
| Immunogen | Full length human recombinant protein of human SNAI2 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, an additional desalting step is recommended (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Slug (SNAI2) is a member of the Snail family of C2H2-type zinc finger transcription factors. It plays a key role in epithelial-mesenchymal transition (EMT) and neural tube formation during embryogenesis.
Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-β. Once expressed, it binds to E-box regions of promoters and represses transcription of genes including E-cadherin and Claudin-1.
Its overexpression has been correlated with poor prognosis in several carcinomas (breast, esophageal, colorectal). Additionally, Slug can protect hematopoietic progenitor cells from radiation-induced apoptosis by repressing p53-mediated transcription of Puma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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