Thermo Fisher Scientific TROP2 Polyclonal Antibody
TROP2 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응. WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. 고순도 Affinity 정제 및 2 mg/mL 농도의 액상 형태. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 27–270 of human TROP-2 (NP_002344.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914747 |
Product Specific Information
- Positive test controls: BxPC-3, A-431, Mouse kidney
- Subcellular location: Membrane, Single-pass type I membrane protein
Immunogen sequence:
HTAAQDNCTC PTNKMTVCSP DGPGGRCQCR ALGSGMAVDC STLTSKCLLL KARMSAPKNA RTLVRPSEHA LVDNDGLYDP DCDPEGRFKA RQCNQTSVCW CVNSVGVRRT DKGDLSLRCD ELVRTHHILI DLRHRPTAGA FNHSDLDAEL RRLFRERYRL HPKFVAAVHY EQPTIQIELR QNTSQKAAGD VDIGDAAYYF ERDIKGESLF QGRGGLDLRV RGEPLQVERT LIYYLDEIPP KFSM
Target Information
TROP2 is a carcinoma-associated antigen defined by the monoclonal antibody GA733. It belongs to a family of type I membrane proteins and functions as a cell surface receptor that transduces intracellular calcium signals. Mutations in the TROP2 gene cause gelatinous drop-like corneal dystrophy, an autosomal recessive disorder leading to corneal amyloidosis and blindness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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