Thermo Fisher Scientific RFWD2 Monoclonal Antibody (1E4)
RFWD2 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체(1E4). Western blot과 ELISA에 적합하며, 인간 및 마우스 시료에 반응. Affinity chromatography로 정제된 액상 항체로, 보존제 무첨가. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-Dependent |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E4 |
| Immunogen | RFWD2 (NP_071902, 632–731 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
CLRSFKGHIN EKNFVGLASN GDYIACGSEN NSLYLYYKGL SKTLLTFKFD TVKSVLDKDR KEDDTNEFVS AVCWRALPDG ESNVLIAANS QGTIKVLELV
Target Information
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins.
E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme and transfer it to targeted substrates.
Involved in JUN and p53 (TP53) ubiquitination and degradation, thereby regulating transcription and apoptosis.
Functions as the essential RING domain subunit of larger E3 complexes.
Also involved in 14-3-3 protein sigma/SFN ubiquitination and degradation, leading to AKT activation and cell survival.
Ubiquitinates MTA1 and CEBPA (upon binding to TRIB1).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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