Thermo Fisher Scientific PSMA7 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, mouse brain
• Predicted reactivity: Mouse (98%), Rat (98%), Xenopus laevis (97%), Pig (98%), Chicken (96%), Bovine (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays essential roles by associating with different regulatory particles.
When associated with two 19S regulatory particles, it forms the 26S proteasome, participating in ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome maintains protein homeostasis by removing misfolded or damaged proteins and proteins no longer needed.
Association with PA200 or PA28 enables ubiquitin-independent protein degradation, required in pathways such as spermatogenesis (20S–PA200 complex) or generation of MHC class I antigenic peptides (20S–PA28 complex).
Inhibits HIF-1A transactivation under normoxic and hypoxic conditions. Interaction with EMAP2 enhances proteasome-mediated HIF-1A degradation under hypoxia. Plays roles in hepatitis C virus translation and androgen receptor nuclear translocation, enhancing androgen-mediated transactivation.

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.