Thermo Fisher Scientific PSMA7 Polyclonal Antibody
Thermo Fisher Scientific의 PSMA7 Polyclonal Antibody는 인간 및 생쥐에서 반응하며, Western blot과 IHC(P) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제된 비결합 항체로, 20S 프로테아좀 복합체 연구에 유용합니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 10–247 of Proteasome 20S alpha 7 (Uniprot ID: O14818) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.32 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11153761 |
Product Specific Information
- Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, mouse brain
- Predicted reactivity: Mouse (98%), Rat (98%), Xenopus laevis (97%), Pig (98%), Chicken (96%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays essential roles by associating with different regulatory particles.
When associated with two 19S regulatory particles, it forms the 26S proteasome, participating in ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome maintains protein homeostasis by removing misfolded or damaged proteins and proteins no longer needed.
Association with PA200 or PA28 enables ubiquitin-independent protein degradation, required in pathways such as spermatogenesis (20S–PA200 complex) or generation of MHC class I antigenic peptides (20S–PA28 complex).
Inhibits HIF-1A transactivation under normoxic and hypoxic conditions. Interaction with EMAP2 enhances proteasome-mediated HIF-1A degradation under hypoxia. Plays roles in hepatitis C virus translation and androgen receptor nuclear translocation, enhancing androgen-mediated transactivation.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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