Thermo Fisher Scientific ACY1 Monoclonal Antibody (OTI1E5), TrueMAB

Applications

ELISA (ELISA)

• Tested Dilution: 1:100–1:1,000

Luminex (LUM)

• Tested Dilution: 1:100–1:1,000

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Target Information

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It functions in the catabolism and salvage of acylated amino acids.
This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression is often reduced or undetectable in SCLC cell lines and tumors.
Human aminoacylase-1 shows high homology with the porcine enzyme and is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, characterized by CNS defects and increased urinary excretion of N-acetylated amino acids.
Alternative splicing results in multiple transcript variants, and read-through transcription occurs between ACY1 and the upstream ABHD14A gene. A related pseudogene exists on chromosome 18.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.