Thermo Fisher Scientific Lamin A/C Recombinant Rabbit Monoclonal Antibody (4L8Q0)
Lamin A/C 단백질을 인식하는 재조합 토끼 단일클론 항체로, Western blot, IHC, ICC, ELISA, IP 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:50,000–1:300,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:4,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:800 | - |
| ELISA | 1 µg/mL | - |
| Immunoprecipitation (IP) | 0.5–4 µg antibody for 200–400 µg extracts | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4L8Q0 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 403–572 of human Lamin A/C (NP_733821.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.24 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2849186 |
Product Specific Information
Immunogen sequence:
SSHSSQTQGG GSVTKKRKLE STESRSSFSQ HARTSGRVAV EEVDEEGKFV RLRNKSNEDQ SMGNWQIKRQ NGDDPLLTYR FPPKFTLKAG QVVTIWAAGA GATHSPPTDL VWKAQNTWGC GNSLRTALIN STGEEVAMRK LVRSVTVVED DEDEDGDDLL HHHHGSHCSS
Target Information
Lamins are intermediate filament proteins forming a matrix on the inner surface of the nuclear envelope. They exist in three forms (A, B, and C) and are expressed in various cell types. Lamins A and C are alternatively spliced products of the LMNA gene.
Mutations in LMNA are associated with several disorders including:
- Emery-Dreifuss muscular dystrophy
- Dunnigan-type familial partial lipodystrophy (FPLD)
- Limb-girdle muscular dystrophy (LGMD1B)
- Dilated cardiomyopathy (CMD1A)
- Axonal neuropathy (CMT2B1)
- Mandibuloacral dysplasia (MAD)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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