Thermo Fisher Scientific HMGB1 Recombinant Rabbit Monoclonal Antibody (1C4T5)
HMGB1 단백질을 표적하는 Thermo Fisher의 재조합 토끼 단클론 항체로, WB, IHC, ICC, ELISA 등 다양한 응용 가능. 높은 특이성과 민감도를 제공하며 HEK293 세포에서 발현. 연구용으로만 사용.
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Thermo Fisher Scientific HMGB1 Recombinant Rabbit Monoclonal Antibody (1C4T5)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:6,000–1:60,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:800 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1C4T5 |
| Immunogen | Synthetic peptide corresponding to amino acids 100–200 of human HMGB1 (P09429) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.65 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849188 |
Product Specific Information
Immunogen sequence:
SAFFLFCSEY RPKIKGEHPG LSIGDVAKKL GEMWNNTAAD DKQPYEKKAA KLKEKYEKDI AAYRAKGKPD AAKKGVVKAE KSKKKKEEEE DEEDEEDEEE E
Target Information
HMGB1 (High-mobility group box-1) protein is a nuclear non-histone DNA-binding chromosomal protein. It can be released from damaged or necrotic cells, functioning as a proinflammatory cytokine.
Mouse HMGB1 consists of a 215 amino acid single-chain polypeptide with three domains:
- Two tandem-linked positively charged DNA-binding domains (HMG box A: aa 9–79, box B: aa 89–162)
- A negatively charged 30 aa C-terminal acidic tail region
Residues 28–44 and 180–185 contain nuclear localization signals (NLS).
The B box mediates cytokine activity, while the A box is linked to transcription factor domains.
HMGB1 promotes monocyte migration, cytokine secretion, and T cell–dendritic cell interactions.
It signals via receptors such as RAGE, TLR2, and TLR4, acting as a mediator of inflammation in sterile and infection-associated responses.
HMGB1 levels are elevated in conditions such as tissue injury, sepsis, arthritis, and ischemia-reperfusion injury.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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