Thermo Fisher Scientific ESR1 Monoclonal Antibody (OTI3G2), TrueMAB
ESR1 단백질을 인식하는 Mouse IgG2a 단일클론 항체로 Western blot 및 IHC(P) 적용 가능. 인간, 마우스, 개 반응성. 무보존제, 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도 유지. 연구용으로만 사용 가능.
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Thermo Fisher Scientific ESR1 Monoclonal Antibody (OTI3G2), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3G2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–310 of human ESR1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Estrogen Receptors (ER) belong to the steroid/thyroid hormone receptor superfamily of nuclear receptors.
ERs are ligand-activated transcription factors that, upon binding to estrogen, undergo conformational changes enabling dimerization and DNA binding to estrogen response elements (EREs).
ERs regulate gene transcription positively or negatively through coactivator or corepressor recruitment.
Two forms exist—alpha (ESR1) and beta (ESR2)—encoded by separate genes.
At least four alpha isoforms are known (66 kDa, 53 kDa, 47 kDa, 35 kDa).
ERs are essential for sexual development, reproductive function, and play roles in bone and other tissues.
They are implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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