Thermo Fisher Scientific Gemin 5 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Positive Samples: HeLa

Immunogen sequence:
RTPVKLESID GNEEESMKEN SGPVENGVSD QEGEEQAREP ELPCGLAPAV SREPVICTPV SSGFEKSKVT INNKVILLKK EPPKEKPETL IKKRKARSLL PLSTSLDHRS KEELHQDCLV LATAKHSREL NEDVSADVEE RFHLGLFTDR ATLYRMIDIE GKGHLENGHP ELFHQLMLWK GDLKGVLQTA AERGELTDNL V

Target Information

The SMN complex plays a catalytic role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and is important in pre-mRNA splicing. Most spliceosomal snRNPs contain a common set of Sm proteins (SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG) that assemble into a heptameric ring on the Sm site of small nuclear RNA to form the core snRNP.
In the cytosol, Sm proteins are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A. The SMN complex dissociates CLNS1A and transfers Sm proteins to form SMN-Sm complexes, triggering core snRNP assembly and nuclear transport. GEMIN5 acts as the snRNA-binding protein of the SMN complex.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.