Thermo Fisher Scientific SERPINC1 Monoclonal Antibody (2B12)
인체 SERPINC1 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체(2B12). Western blot과 ELISA에 적합하며, 항응고 관련 연구에 활용 가능. Mouse IgG2b, kappa 형식이며 액상 형태로 제공. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2B12 |
| Immunogen | SERPINC1 (AAH22309.1, 1–259 a.a) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MYSNVIGTVT SGKRKVYLLS LLLIGFWDCV TCHGSPVDIC TAEPRDIPMN PMCIYRSPEK KATEDEGSEQ KIPEATNRRV WELSKANSRF ATTFYQHLAD SKNDNDNIFL SPLSISTAFA MTKLGACNDT LQQLMEVFKF DTISEKTSDQ IHFFFAKLNC RLYRKANKSS KLVSANRLFG DKSLTFNDLY VSDAFHKAFL EVNEEGSEAA ASTAVVIAGR SLNPNRVTFK ANRPFLVFIR EVPLNTIIFM GRVANPCVK
Target Information
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. It inhibits thrombin and other activated serine proteases of the coagulation system, regulating the blood coagulation cascade.
It includes two functional domains:
- Heparin binding-domain: N-terminus of the mature protein
- Reactive site domain: C-terminus
The inhibitory activity is enhanced by the presence of heparin. Over 120 mutations have been identified for this gene, many of which are associated with antithrombin-III deficiency.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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