Thermo Fisher Scientific PTPRK Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total PTPRK.

Target Information

Protein tyrosine phosphatases (PTPs) are type I transmembrane proteins, membrane-associated proteins, or nuclear proteins. Examples include LAR, PTP alpha, PTP beta, PTP gamma, PTP delta, PTP epsilon, PTP zeta, PTPk, and PTP-mu.
Transmembrane PTPs play diverse roles during development and in adult tissues.

• LAR regulates insulin receptor phosphorylation.
• PTP alpha activity increases twofold upon phorbol ester stimulation, involving PKC family-mediated phosphorylation.
• Overexpression of v-H-ras and Neu induces PTP epsilon expression in mammary tumors.
• Alternative splicing produces phosphacan, a nervous tissue-specific chondroitin sulfate proteoglycan derived from PTP zeta.
• PTPk and PTP-mu share a conserved 160 amino acid MAM domain facilitating homophilic binding.
• PTP-mu localizes to cell contact points and may regulate cadherin/catenin complex assembly/disassembly.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.