Thermo Fisher Scientific RRAS2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total RRAS2.

Target Information

RRAS2 is involved in activating mutations and the overexpression of classical Ras subfamily members (K-RAS, N-RAS, and H-RAS), which have been widely investigated as key events in the development of human cancers.
The RRAS subfamily of Ras-related proteins includes RRAS1, RRAS2 (TC21), and RRAS3 (M-Ras), showing overall amino acid identity with the classical Ras subfamily (H-Ras, K-Ras, and N-Ras) of 55–60%.
RRAS2 is a small GTP-binding protein of the Ras superfamily of GTPases. It may transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with Ras proteins.
RRAS2 has high oncogenic potential, and overexpression or mutations have been reported in several tumor tissues and cell lines.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.