Thermo Fisher Scientific Nanog Monoclonal Antibody (23D2-3C6)
Nanog 단백질을 특이적으로 인식하는 mouse monoclonal antibody로, Western blot, IHC, ICC/IF, Flow Cytometry 등 다양한 응용 가능. 배아줄기세포 연구 및 pluripotency 관련 연구에 적합. 단백질 A 정제, PBS/BSA buffer, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 | View 7 publications |
| Flow Cytometry (Flow) | Assay-dependent | View 1 publication |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Marsupial, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 23D2-3C6 |
| Immunogen | Full-length human recombinant Nanog protein (aa 1–305) expressed in bacteria |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1 mg/mL BSA, 30% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536677 |
Additional Formats
Product Specific Information
Western blot analysis of MA1-017 detects an ~38 kDa protein in embryonal carcinoma cells. Subcellular fractionation shows nuclear localization of Nanog. MA1-017 shows specificity to Nanog and is non-reactive to lysates from non-embryonal cell types (e.g., HeLa cell lysate).
Target Information
NANOG (Nanog homeobox) is a divergent homeodomain protein that regulates pluripotency and differentiation of undifferentiated embryonic stem cells. NANOG mRNA is present in pluripotent mouse and human cell lines and absent from differentiated cells.
Human NANOG shares 52% overall amino acid identity with the mouse protein (85% in the homeodomain).
- Human NANOG gene locus: 12p13.31
- Mouse NANOG locus: 6 F2
Murine embryonic NANOG expression is detected in the inner cell mass of the blastocyst. High levels of human NANOG are observed in undifferentiated N-Tera embryonal carcinoma cells. NANOG acts as a transcription regulator involved in inner cell mass and embryonic stem (ES) cell proliferation and self-renewal.
Its role in embryonic development suggests potential applications in generating stem cells for regenerative medicine. Induced pluripotent stem (iPS) cells can be created by expressing NANOG along with Sox2, Klf4, Lin28, and c-Myc. Such non-viral reprogramming methods address safety concerns for clinical applications. Overexpression of NANOG promotes S-phase entry and proliferation.
Diseases associated with NANOG dysfunction include teratocarcinoma and germ cell/embryonal cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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