Thermo Fisher Scientific SFTPB Polyclonal Antibody
Human SFTPB 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:1,000–1:2,500 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 완충액에 보관. 폐 계면활성 단백질 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SFTPB. Recombinant protein control fragment (Product #RP-104124) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2791686 |
Product Specific Information
Immunogen sequence:
PLVIDYFQNQ IDSNGICMHL GLCKSRQPEP EQEPGMSDPL PKPLRDPLPD PLLDKLVLPV LPGALQARPG PHTQDLS
Target Information
Pulmonary surfactant is a complex mixture of phospholipids and proteins secreted from type II alveolar cells, reducing surface tension at the alveolar air-liquid interface to maintain alveolar stability during normal ventilation. Four distinct surfactant proteins are identified: SP-A, SP-B, SP-C, and SP-D.
- SP-A (28–36 kDa) and SP-D (43 kDa): Collagenous carbohydrate-binding proteins
- SP-B (8–9 kDa) and SP-C (4 kDa): Non-collagenous hydrophobic proteins
SP-B is expressed in pulmonary adenocarcinomas with acinar, papillary, bronchioloalveolar, and solid growth patterns. Squamous cell and large cell carcinomas of the lung and nonpulmonary adenocarcinomas do not express SP-B. ProSP-B is glycosylated in the Golgi apparatus and undergoes carboxy- and amino-terminal proteolysis by a cathepsin D-like protease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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