Thermo Fisher Scientific SHH Polyclonal Antibody
SHH 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western Blot, ICC/IF, ELISA에 사용 가능. 인간 샘플 반응성, 고순도 Affinity Chromatography 정제, 액상 형태로 -20°C 보관. 세포막 및 세포외 위치 검출에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 231–330 of human Sonic Hedgehog (Shh) (NP_000184.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.41 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805022 |
Product Specific Information
- Positive Samples: A-549
- Cellular Location: Cell membrane, Lipid-anchor, extracellular space
- Immunogen Sequence:
GRLLYSDFLT FLDRDDGAKK VFYVIETREP RERLLLTAAH LLFVAPHNDS ATGEPEASSG SGPPSGGALG PRALFASRVR PGQRVYVVAE RDGDRRLLPA
Target Information
Sonic Hedgehog (SHH), expressed during embryogenesis, plays a critical role in patterning the early embryo. It is a key inductive signal in ventral neural tube formation, limb axis development, and somite patterning. The human SHH protein is most similar to the Drosophila counterpart. It is synthesized as a precursor that undergoes autocatalytic cleavage:
- N-terminal portion: Soluble and responsible for signaling activity
- C-terminal portion: Involved in precursor processing and attaches a cholesterol moiety to the N-terminal product, anchoring it to the cell surface
Defects in SHH or its pathway can cause holoprosencephaly (HPE), characterized by improper forebrain division and facial deformities, and may also contribute to VACTERL syndrome involving multiple congenital anomalies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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