Thermo Fisher Scientific GAD67 Polyclonal Antibody
GAD67 단백질을 검출하기 위한 Thermo Fisher Scientific의 고순도 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF 등 다양한 응용에 적합하며, 인간·마우스·랫트 시료에서 반응. 항원 친화 크로마토그래피로 정제된 고품질 항체로 안정적인 신경전달 관련 연구에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein of human GAD67/GAD67/GAD1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803895 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and catalyze the rate-limiting step in GABA (gamma-aminobutyric acid) synthesis from L-glutamic acid.
Both are found in the brain:
- GAD-65 localizes to synaptic vesicle membranes in nerve terminals.
- GAD-67 is distributed throughout the cell and maintains basal GABA synthesis.
Under increased neurotransmission demand, GAD-65 transiently activates to assist GABA production. Loss of GAD-65 impairs neurotransmission, while loss of GAD-67 is lethal.
Alternative splicing produces two isoforms: predominant GAD-67 and minor GAD-25.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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