Thermo Fisher Scientific CRYAB Monoclonal Antibody (OTI2A1), TrueMAB
CRYAB 단백질을 표적하는 Mouse IgG1 모노클로날 항체로, Western blot, IHC, ICC/IF, Flow cytometry 등에 사용 가능. 고순도 친화 크로마토그래피 정제, 1 mg/mL 농도, 안정적 액상 형태로 -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2A1 |
| Immunogen | Full length human recombinant protein of human CRYAB produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index of the lens.
The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest of the crystallins and is composed of two primary gene products—alpha-A and alpha-B.
Alpha-crystallin comprises about 40% of total lens protein composition. In addition to maintaining the proper refractive index, it also functions in a chaperone-like manner by preventing the formation of aggregates that could lead to cataract formation.
Phosphorylated states of alpha-crystallin occur in response to cellular stress and may serve structural control and protein maintenance roles. Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells of affected individuals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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