Thermo Fisher Scientific BSEP Vesicular Transport Assay Reagent Set

Gibco™ BSEP Vesicular Transport Assay Reagent Set

The BSEP Vesicular Transport Assay Reagent Set is a ready-to-use kit containing all reagents needed for vesicular transport assay except for the vesicles themselves.
This reagent set can be used for vesicular transport assays using radioisotope-labeled or non-labeled compounds.
Each kit provides sufficient material to perform 100 vesicular transport assays.

Applications

Use the BSEP Vesicular Transport Assay Reagent Set to:

• Investigate transporter interactions of drug candidates
• Assess potential for transporter-mediated drug-drug interactions
• Obtain high-quality results with large signal-to-noise ratios

Concept Behind ABC Transporter Vesicles

ABC transporter vesicles are efficient reagents for early assessment of drug candidate substrate and drug interaction potential.
While ABC transporters typically mediate the export of substrates out of cells, transporters expressed on these inside-out vesicles import substrates into the vesicles.
This allows quantitative evaluation of transport activity by determining the amount incorporated into the vesicles.

Clear and Reliable Results

Prepared from Sf9 cells engineered to over-express specific ABC transporters, these inside-out vesicles provide:

• High levels of transporter activity
• Low background noise
• Clear signals for identifying substrates or inhibitors of specific efflux transporters

Kit Compatibility

The BSEP Vesicular Transport Assay Reagent Set is designed for use with BSEP Vesicles.
Performing 100 vesicular transport assays with this kit will require two BSEP Vesicle products.

For Research Use Only. Not intended for animal or human therapeutic or diagnostic use.

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