Thermo Fisher Scientific Human NTCP (G) SLC Transporter Cells
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Gibco™
Human NTCP (G) SLC Transporter Cells
TRANSiPORT Human NTCP (G) SLC Transporter Cells are HEK293 cells that transiently overexpress the NTCP solute carrier (SLC) transport protein.자세히 알아보기
TRANSiPORT Human NTCP (G) SLC Transporter Cells are HEK293 cells that transiently overexpress the NTCP solute carrier (SLC) transport protein. Solute carriers are a super-family of membrane transporters that can affect pharmacokinetics and drug exposure by governing the transport of solutes in and out of cells. The NTCP SLC transporter protein is found in hepatocytes.
• Assess potential for transporter-mediated drug metabolism
• Easy to use format
• Obtain high quality results with a large signal-to-noise ratio
Choice of measurement system
Cell-based assays can be performed using radioisotope-labeled compounds, fluorescence-labeled compounds, or non-labeled compounds. The amount of substrate transported into the cells can be measured directly using a liquid scintillation counter, fluorescence plate reader, or LC-MS/MS, thereby allowing direct evaluation of SLC transporter activity.
Assay reliability
Mock HEK293 cells (Cat. No. GM1101G) that do not overexpress the SLC transporter are available for use as a negative experimental control. Some compounds may demonstrate high background levels of transport due to the presence of endogenous transporters or non-specific binding.
Rapid results
The convenient product format enables data generation in 2 days from thawing of the cells to final results.
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GM1101G Mock Cells
사양
세포주293 (HEK)
Culture TypeMammalian Cell Culture
종Human
셀 수8-10 x 106
제품 유형SLC Transporter Cell
수량8–10M cells
Unit SizeEach
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