Thermo Fisher Scientific SAP18 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SAP18. Recombinant protein control fragment (Product #RP-89364). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SAP18,uniProtId:O00422-1,ncbiNodeId:9606,antigenRange:7-145,antigenLength:153,antigenImageFileName:PA5-52821_SAP18_O00422-1_Rabbit.svg,antigenImageFileNamePDP:PA5-52821_SAP18_O00422-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2646939

Product Specific Information

Immunogen sequence: VTQEEIKKEP EKPIDREKTC PLLLRVFTTN NGRHHRMDEF SRGNVPSSEL QIYTWMDATL KELTSLVKEV YPEARKKGTH FNFAIVFTDV KRPGYRVKEI GSTMSGRKGT DDSMTLQSQK FQIGDYLDIA ITPPNRAPP

Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.

Target Information

SAP18 is involved in histone acetylation, which plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.