Thermo Fisher Scientific SAP18 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human SAP18 protein. Validated for IHC(P) and ICC/IF applications. Antigen affinity purified and supplied in PBS with glycerol. Suitable for research on histone acetylation and gene expression regulation.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | View 1 publication |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SAP18. Recombinant protein control fragment (Product # RP-89364) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2646939 |
Product Specific Information
Immunogen sequence:
VTQEEIKKEP EKPIDREKTC PLLLRVFTTN NGRHHRMDEF SRGNVPSSEL QIYTWMDATL KELTSLVKEV YPEARKKGTH FNFAIVFTDV KRPGYRVKEI GSTMSGRKGT DDSMTLQSQK FQIGDYLDIA ITPPNRAPP
Sequence identity:
Highest antigen sequence identity to the following orthologs:
- Mouse: 99%
- Rat: 99%
Target Information
SAP18 is involved in histone acetylation, a key process in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
배송 정보
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