Thermo Fisher Scientific ZP2 Polyclonal Antibody
Thermo Fisher Scientific ZP2 폴리클로날 항체는 인간 ZP2 단백질을 인식하는 Rabbit IgG 기반 항체로, IHC(P) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS 버퍼와 글리세롤로 안정화되어 있습니다. 연구용으로만 사용 가능합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ZP2. Recombinant protein control fragment (Product #RP-90072) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2650389 |
Product Specific Information
Immunogen sequence:
PNCTYILDPE KLTLRATYDN CTRRVHGGHQ MTIRVMNNSA ALRHGAVMYQ FFCPAMQVEE TQGLSASTIC QKDFMSFSLP RVFSGLADDS KGTKVQMGWS IEVGDGARAK TLTLPEAMKE GFSLLIDNHR MTFHVPFNAT GVT
Highest antigen sequence identity to the following orthologs:
- Mouse: 45%
- Rat: 45%
Target Information
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa.
The nascent protein contains:
- N-terminal signal peptide sequence
- Conserved ZP domain
- Consensus furin cleavage site
- C-terminal transmembrane domain
It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage remains controversial based on mouse studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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