Thermo Fisher Scientific CD38 Monoclonal Antibody (OTI6B3), TrueMAB

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 1:50

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes and mediates apoptosis of myeloid and lymphoid progenitor cells.

It functions as a multi-catalytic ectoenzyme serving as:

• ADP-ribosyl cyclase
• Cyclic ADP-ribose hydrolase
• NAD⁺ glycohydrolase
• Cell surface receptor

Antibodies to CD38 are useful for:

• Subtyping lymphomas and leukemias
• Detection of plasma cells (e.g., identification of myelomas)
• Marker for activated B and T cells

CD38 participates in cell adhesion, signal transduction, and calcium signaling, and is highly expressed in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.