Thermo Fisher Scientific UFD1L Polyclonal Antibody, FITC
FITC로 표지된 UFD1L 폴리클로날 항체로, Western blot, ELISA, IP 등 다양한 응용에 적합합니다. 사람, 마우스, 랫트 시료에서 반응하며, 고순도 친화 크로마토그래피로 정제되었습니다. 형광 특성(Ex/Em 498/517 nm)을 가지며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Purified 20 kDa UFD1L protein |
| Conjugate | FITC (Fluorescein isothiocyanate) |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Ubiquitin-mediated proteolysis involves the transfer of ubiquitin (Ub) to lysine residues on target proteins, promoting their degradation by the 26S proteasome. Ub-fusions can be processed by Ub-specific proteases (UBps) or by the Ub-fusion degradation (UFD) pathway. The UFD1 protein, first identified in yeast (S. cerevisiae) and later in humans as UFD1L, modulates the degradation of Ub-fusions with specific amino acid substitutions at the Gly76 site. Mutations in the UFD1 gene are associated with CATCH22 syndrome, characterized by cardiac defects, cleft palate, and hypocalcemia, suggesting a role in developmental processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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