Thermo Fisher Scientific UFD1L Polyclonal Antibody, Biotin
UFD1L 단백질을 인식하는 Thermo Fisher Scientific의 Biotin 결합 폴리클로날 항체입니다. Western blot, ELISA, IP 등 다양한 응용에 적합합니다. Human, Mouse, Rat 반응성. 고순도 친화 크로마토그래피 정제. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 1:50–1:250
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Purified 20 kDa UFD1L protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Ubiquitin-mediated proteolysis involves the transfer of ubiquitin (Ub) to lysine residues on specific cellular proteins, leading to degradation by the 26S proteasome. Ub-fusions are processed by Ub-specific proteases (UBps) or the Ub-fusion degradation (UFD) pathway. The UFD1 protein, first identified in yeast (S. cerevisiae), has a human homolog UFD1L. In vitro, UFD1 attenuates degradation of Ub-fusions with specific amino acid substitutions at the Gly76 residue. Mutations in the UFD1 gene are linked to CATCH22 syndrome, characterized by cardiac defects, cleft palate, and hypocalcemia, suggesting involvement in developmental proteolytic regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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