Thermo Fisher Scientific GFRA1 Monoclonal Antibody (4D8)
GFRA1 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체(4D8)로, 인간 시료에 반응하며 ICC/IF 및 ELISA에 적합합니다. 액상 형태로 제공되며, 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4D8 |
| Immunogen | GFRA1 (NP_005255, 32 a.a. ~119 a.a.) full length recombinant protein with GST tag. MW of GST tag alone: 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
ASDQCLKEQS CSTKYRTLRQ CVAGKETNFS LASGLEAKDE CRSAMEALKQ KSLYNCRCKR GMKKEKNCLR IYWSMYQSLQ GNDLLEDS
Target Information
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nervous system. Physiological responses to GDNF require the presence of a glycosylphosphatidylinositol-linked protein, GDNFRα, which acts as a cell surface receptor for GDNF. The cDNAs encoding GDNFRα from human, rat, chicken, and mouse have been cloned. GDNFRα, also known as Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1), is now designated as GFRα-1. GFRα-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Together, GDNF, GFRα, and Ret PTK form a complex to transduce GDNF signaling and mediate its biological function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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