Thermo Fisher Scientific GFRA1 Monoclonal Antibody (1G4)
GFRA1 단백질을 표적하는 Thermo Fisher Scientific의 마우스 단클론 항체로, WB, ICC/IF, ELISA에 적합합니다. 인간 시료 반응성이 있으며, 액상 형태로 제공되고 PBS 버퍼에 보존제 없이 저장됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1G4 |
| Immunogen | GFRA1 (NP_005255, 32–119 a.a.) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
ASDQCLKEQS CSTKYRTLRQ CVAGKETNFS LASGLEAKDE CRSAMEALKQ KSLYNCRCKR GMKKEKNCLR IYWSMYQSLQ GNDLLEDS
Target Information
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nervous system. Physiological responses to GDNF require the presence of a glycosylphosphatidylinositol-linked protein GDNFRα, which acts as a cell surface receptor for GDNF.
GDNFRα (also known as Ret ligand 1, TGF-beta-related neurotrophic factor receptor 1, or GFR-α-1) binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Together, GDNF, GFR-α, and Ret PTK form a complex that transduces GDNF signaling and mediates its biological functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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