Thermo Fisher Scientific GABARAP Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Bovine, Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues P(33) H L P R P H P R V P P H P S S E R R A V Y(54) of the mouse and rat GABA R1 subunit. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:GABARAP,uniProtId:P60517-1,ncbiNodeId:10114,antigenRange:33-54,antigenLength:117,antigenImageFileName:PA1-4147_GABARAP_P60517-1_Rabbit.svg,antigenImageFileNamePDP:PA1-4147_GABARAP_P60517-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2108010

Product Specific Information

PA1-4147 detects GABA Receptor Associated Protein in human, rat, mouse, bovine, and non-human primate samples.

PA1-4147 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~116 kDa protein representing GABA Receptor Associated Protein in brain lysate.

The PA1-4147 immunogen is a synthetic peptide corresponding to residues P(33) H L P R P H P R V P P H P S S E R R A V Y(54) of the mouse and rat GABA R1 subunit.

Target Information

Gamma-aminobutyric acid (GABA) is the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing in the central nervous system. It has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. GABARAP (GABAA receptor-associated protein) links GABAA receptors to the cytoskeleton and may play a role in intracellular transport of GABAA receptors and its interaction with the cytoskeleton. GABARAP belongs to the MAP1 or ATG8 like family and recent studies show that MAPK15/ERK8 is acting through interaction with ATG8 family proteins to regulate autophagy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.