Thermo Fisher Scientific PDE1B Polyclonal Antibody
Human PDE1B 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 최적화됨. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 액상 형태로 4°C 단기, -20°C 장기 보관 가능. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PDE1B. Recombinant protein control fragment (Product #RP-92038). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645324 |
Product Specific Information
Immunogen sequence:
TFSVLTDVAE KSVQPLADED SKSKNQPSFQ WRQPSLDVEV GDPNPDVVSF RSTWVKRIQE NKQKWKERAA SGITNQMSID ELSPCEEEAP PSPAEDEHNQ NGN
Highest antigen sequence identity to the following orthologs:
- Mouse: 92%
- Rat: 93%
Target Information
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, specifically the PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers cAMP and cGMP, with a preference for cGMP as a substrate.
cAMP and cGMP function as key regulators of many important physiological processes.
Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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