Thermo Fisher Scientific ORC1 Monoclonal Antibody (7F6/1)
인간 ORC1 단백질을 인식하는 마우스 단일클론 항체로, ELISA 등 다양한 연구용 분석에 적합. 단백질 복제 개시 관련 연구에 활용 가능. 단백질 A/G로 정제된 액상형 항체이며, 보존제가 없는 PBS 용액 형태로 제공. -20°C에서 보관 필요.
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Applications
- ELISA (ELISA)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7F6/1 |
| Immunogen | Recombinant full-length human ORC1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The origin recognition complex (ORC) is a highly conserved six-subunit protein complex essential for the initiation of DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins.
The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, controlled by ubiquitin-mediated proteolysis after initiation of DNA replication.
This protein is selectively phosphorylated during mitosis and interacts with MYST histone acetyltransferase 2 (MyST2/HBO1), which is involved in transcription silencing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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