Thermo Fisher Scientific ORC1 Monoclonal Antibody (7F6/1)
Human ORC1 단백질을 인식하는 Mouse IgG1 단클론 항체로, ELISA 등 연구용 분석에 적합합니다. Recombinant full-length ORC1을 면역원으로 사용했으며, 단백질 A/G로 정제된 액상 형태입니다. PBS/BSA buffer에 보관하며 4°C에서 안정적입니다.
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Applications
- ELISA (ELISA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7F6/1 |
| Immunogen | Recombinant full-length human ORC1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The origin recognition complex (ORC) is a highly conserved six-subunit protein complex essential for the initiation of DNA replication in eukaryotic cells. Studies in yeast have shown that ORC binds specifically to origins of replication and serves as a platform for assembling additional initiation factors such as Cdc6 and Mcm proteins.
The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits remain stable throughout the cell cycle, the levels of this protein vary and are controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is selectively phosphorylated during mitosis and interacts with MYST histone acetyltransferase 2 (MyST2/HBO1), which is involved in transcriptional silencing control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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