Thermo Fisher Scientific CREB Polyclonal Antibody
CREB 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot과 IHC(P)에서 검증됨. 인간 및 생쥐 반응성. 액상 형태, 0.5 mg/mL 농도. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–0.3 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-DSQESVDSVTDSQK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933720 |
Product Specific Information
This antibody is expected to recognize both reported isoforms (NP_004370.1; NP_604391.1).
Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to various extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors.
Activation of CREB is dependent upon phosphorylation of serine 133. Phosphorylation occurs via p44/42 MAP kinase, p90RSK, p38 MAP kinase, and MSK1. Although CREB binds DNA regardless of phosphorylation, only the phosphorylated form acts as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator, interacts with CREB at serine 133.
CREB is involved in cellular processes such as circadian rhythm synchronization, adipocyte differentiation, and learning and memory. In humans, the gene is located on chromosome 2q.
Diseases associated with CREB dysfunction include Alzheimer’s disease, histiocytoma, and soft tissue melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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