Thermo Fisher Scientific MPP5 Polyclonal Antibody
MPP5 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 적합합니다. 인간 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 극성 유지 및 신경 발생 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100–1:400 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein Membrane Protein, Palmitoylated 5 (amino acids 455–675 of the target protein) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903774 |
Target Information
MPP5 (Membrane Protein, Palmitoylated 5) plays a critical role in neurogenesis and hematopoiesis. It is essential for establishing and maintaining cell polarity in epithelial cells and neurons. MPP5 is part of the Par-3 complex, contributing to tight junction maintenance in epithelial cells.
Mutations in MPP5 are associated with severe neurological impairments, including global developmental delay (GDD) and behavioral changes. In animal models, MPP5 is involved in early differentiation of multipotent progenitors and supports long-term lineage-specific contributions, particularly in myeloid and lymphoid cells.
MPP5 variants disrupt normal cellular function, leading to developmental and functional abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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