Thermo Fisher Scientific PD-L1/PDCD1LG1/CD274/B7-H1 (Cancer Immunotherapy Target) Monoclonal Antibody (PDL1/2745)
PD-L1 단백질을 표적으로 하는 인간 반응성 마우스 단클론 항체입니다. 암 면역치료 연구용으로 ELISA 및 Peptide Array에 사용 가능합니다. 단백질 A/G로 정제된 액상형 항체이며, 보존제가 없는 PBS 용액에 1 mg/mL 농도로 제공됩니다. 연구용으로만 사용됩니다.
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Applications
ELISA
- Assay-dependent
Peptide Array
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PDL1/2745 |
| Immunogen | Recombinant fragment of human CD274 protein (around aa 39–191) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. One specific receptor, programmed death receptor 1 (PD-1), can be ligated by PD-L1 and negatively regulates T-cell receptor (TCR) signaling. Upon ligation, PD-L1 decreases TCR-mediated proliferation and cytokine production. PD-L1 expression is abundant in many murine and human cancers and can be upregulated upon IFN-gamma stimulation, suggesting its role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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