Thermo Fisher Scientific VEGF Receptor 1 Polyclonal Antibody
Thermo Fisher Scientific의 VEGF Receptor 1 Polyclonal Antibody는 인간 FLT1(VEGFR1)을 특이적으로 인식하는 rabbit IgG 항체입니다. Western blot에 적합하며 VEGFR-2 및 VEGFR-3과 교차 반응하지 않습니다. 항원 친화 크로마토그래피로 정제된 액상 항체로, -20°C에서 보관합니다.
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Applications
Western Blot (WB)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding Thr1307 of human VEGFR-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10985502 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with VEGFR-2 and -3 nor does it detect the sVEGFR-1 variant.
Target Information
FLT1 (VEGFR1) is a receptor tyrosine kinase that plays a critical role in angiogenesis. Active angiogenesis is involved in pathological and physiological processes such as tumor progression, diabetic retinopathy, rheumatoid arthritis, and wound healing.
It may act as a negative regulator of embryonic angiogenesis by inhibiting excessive endothelial cell proliferation. In adulthood, it can promote endothelial cell proliferation, survival, and angiogenesis. Its proliferative function is cell-type specific—promoting PGF-mediated proliferation of endothelial and certain cancer cells but not normal fibroblasts (in vitro).
FLT1 has high affinity for VEGFA and relatively low kinase activity, possibly functioning as a negative regulator of VEGFA signaling by limiting free VEGFA and preventing its binding to KDR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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