Thermo Fisher Scientific Resistin Polyclonal Antibody

Thermo Fisher Scientific Resistin Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1:500–1:1,000
Publications: - [References not provided]

Product Specifications

Target Information

Adipose tissue acts as an energy reserve and is tightly regulated in animals. Adipose cells produce and secrete various physiologically important proteins, such as lipoprotein lipase (LPL), leptin, adipocyte complement related protein of 30 kDa (Acrp30), perilipin, and resistin.

Resistin, also known as Adipocyte Secreted Factor (ADSF) and FIZZ3, is a cytokine secreted specifically by adipocytes. Although its function is not fully understood, resistin appears to play important paracrine roles and is implicated in type 2 diabetes. Studies in obese, diabetic mice show increased serum resistin levels, which antagonize insulin activity. Further research demonstrates that resistin induces insulin resistance and glucose intolerance in mice.

Resistin gene expression requires C/EBP alpha, which is necessary and sufficient for its expression. Coactivators CBP and p300, possessing histone acetyltransferase (HAT) activity, acetylate histones at the resistin promoter, suggesting their role in activating chromatin for resistin transcription. Numerous PPAR gamma and RXR ligands have been shown to downregulate resistin expression in adipocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.