Thermo Fisher Scientific ERAS Polyclonal Antibody
Thermo Fisher Scientific의 ERAS Polyclonal Antibody는 인간 ERAS 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 사용 가능. 합성 펩타이드 기반 면역원으로 제작되었으며, 동결건조 형태로 제공. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal region of human GTPase ERAS conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: ERAS.
Target Information
The human ERAS gene was initially reported as a processed pseudogene (HRasp, Ha-Ras2), with several base substitutions in coding regions, but was later described as potentially encoding a functional human ERAS protein.
The ERAS oncogene supports tumorigenic growth of embryonic stem cells by producing a constitutively active Ras protein.
ERAS protein has less than 50% amino acid identity with H-Ras, another Ras family member, but key domains essential for Ras function are highly conserved.
The protein also contains amino-acid residues identical to those present in active mutants of Ras and causes oncogenic transformation in NIH 3T3 cells.
Human ERAS gene is localized in chromosomal region Xp11.23.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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