Thermo Fisher Scientific SLC1A6 Polyclonal Antibody
SLC1A6 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에 반응합니다. WB 및 IHC에 적합하며 EAAT4 특이성을 가집니다. 동결건조 형태로 제공되며 장기 보관 시 -20°C에서 안정적으로 유지됩니다.
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Thermo Fisher Scientific SLC1A6 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
| Miscellaneous (PubMed) | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from C-terminal region of human Excitatory amino acid transporter 4 (EAAT4, SLC1A6), conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: EAAT4.
Target Information
Slc1a6 encodes a glutamate transporter, also known as an excitatory amino acid transporter (EAAT), part of the solute carrier family 6 (SLC1). EAATs are sodium- and potassium-dependent and widely distributed throughout the brain.
There are five EAAT subtypes, each with specific distribution. SLC1A6 mediates uptake of L-glutamate, L-aspartate, and D-aspartate, functioning as a symporter that transports one amino acid molecule with two or three Na⁺ ions and one proton, coupled with counter-transport of one K⁺ ion.
It also mediates Cl⁻ flux to prevent charge accumulation. SLC1A6 plays a redundant role in rapid removal of released glutamate from the synaptic cleft, essential for terminating postsynaptic glutamate action.
Diseases associated with SLC1A6 include Dicarboxylic Aminoaciduria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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