Thermo Fisher Scientific HNF1A Monoclonal Antibody (622CT11.9.6)

Applications

• Western Blot (WB): 1:100–1:1,600

Product Specifications

Target Information

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region and may play a role in the phenotype of WHS or Pitt-Rogers-Danks syndrome. The encoded protein can react with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting its potential as a target for specific immunotherapy for many cancer patients. It is also a member of the NELF (negative elongation factor) complex involved in RNA polymerase II transcription elongation regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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