Thermo Fisher Scientific COL4A4 Polyclonal Antibody

Thermo Fisher Scientific COL4A4 Polyclonal Antibody

Applications

• Western Blot (WB): 0.01–2 µg/mL

Product Specifications

Target Information

Collagens are highly conserved proteins characterized by an uninterrupted Glycine-X-Y triplet repeat.

• Col1: Fibrillar collagen found in most connective tissues; mutations linked to osteogenesis imperfecta, Ehlers-Danlos syndrome, and idiopathic osteoporosis.
• Col2: Found in cartilage and vitreous humor; mutations associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, and Kniest dysplasia.
• Col3: Found in extensible connective tissues such as skin, lung, and vascular system; mutations linked to Ehlers-Danlos syndrome type IV and arterial aneurysms.
• Col4: Major constituent of basement membranes along with laminins and enactins; composed of α1(IV) and α2(IV) chains in a 2:1 ratio. Useful for detecting basement membrane loss in carcinomas.
• Col5: Found in tissues containing Col1; regulates assembly of heterotypic fibers composed of Col1 and Col5. Mutations associated with Ehlers-Danlos syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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