Thermo Fisher Scientific Ki67 Monoclonal Antibody (OTI5B10), TrueMAB
Ki-67 단백질을 표적하는 Rat IgG1 단클론 항체로, 세포 증식 마커 연구에 적합. 포르말린 고정 파라핀 절편(IHC-P)에서 1:150 희석으로 검증됨. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도 유지. 연구용으로만 사용 가능.
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Applications
- Immunohistochemistry (Paraffin) (IHC-P): Tested dilution 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rat / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5B10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1160–1493 of human MKI67 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Ki-67 is a nuclear protein expressed during late G1, S, G2, and M phases of the cell cycle. It associates with euchromatin at the perichromosomal layer, centromeric heterochromatin, and nucleolus.
Ki-67 shows cell cycle–dependent localization: perinucleolar in G1, nuclear matrix in G2, and chromosomal in M phase.
Because it is absent in G0 cells and increases from G1 through mitosis, Ki-67 is widely used as a proliferation marker.
In neoplasms, Ki-67 index correlates with tumor grade and proliferation rate, serving as a valuable prognostic marker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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