Thermo Fisher Scientific PDE4B Polyclonal Antibody
PDE4B 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체입니다. Western blot 및 IHC(P)에서 검증되었으며, 인간과 마우스에 반응합니다. 합성 펩타이드 면역원으로 제작되었으며, 액상 형태로 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1.0 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (DIDIATEDKSPVDT) corresponding to the C-terminus amino acids of PDE4B (aa 723–736) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10982537 |
Product Specific Information
- Predicted to react with human and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 8,000.
Target Information
The PDE4B gene belongs to the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides act as second messengers regulating cellular responses to extracellular signals such as hormones, light, and neurotransmitters. PDEs control intracellular cyclic nucleotide levels and are key regulators in signal transduction. PDE4B specifically hydrolyzes cAMP, and altered activity has been linked to schizophrenia and bipolar affective disorder. Multiple isoforms are produced via alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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