Thermo Fisher Scientific GSTA3 Monoclonal Antibody (1F11)

Applications

Product Specifications

Product Specific Information

Sequence of this protein is as follows:

MAGKPKLHYF NGRGRMEPIR WLLAAAGVEF EEKFIGSAED LGKLRNDGSL MFQQVPMVEI DGIKLVQTRA ILNYIASKYN LYGKDIKERA LIDMYTEGMA DLNEMILLLP LCRPEEKDAK IALIKEKTKS RYFPAFEKVL QSHGQDYLVG NKLSRADISL VELLYYVEEL DSSLISNFPL LKALKTRISN LPTVKKFLQP GSPRKPPADA KALEEARKIF RF

Target Information

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds.
Eight distinct classes of soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta.
This gene encodes a glutathione S-transferase belonging to the alpha class, located on chromosome 6. Alpha class genes encode enzymes with glutathione peroxidase activity.
During evolution, this alpha class gene diverged, accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity.
The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during steroid hormone biosynthesis.
An additional transcript variant has been identified, but its full-length sequence has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.