Thermo Fisher Scientific GSTA2 Monoclonal Antibody (3D4)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Protein sequence:
MAEKPKLHYS NIRGRMESIR WLLAAAGVEF EEKFIKSAED LDKLRNDGYL MFQQVPMVEI DGMKLVQTRA ILNYIASKYN LYGKDIKEKA LIDMYIEGIA

Target Information

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic, which can affect individual susceptibility to carcinogens and drug efficacy.

Eight distinct classes of soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta, and zeta. This gene encodes a glutathione S-transferase belonging to the alpha class, located on chromosome 6. The alpha class enzymes are abundantly expressed in the liver, where they metabolize bilirubin and certain anti-cancer drugs and exhibit glutathione peroxidase activity, protecting cells from reactive oxygen species and peroxidation products.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.