Thermo Fisher Scientific Protein C Polyclonal Antibody
Rabbit Polyclonal Antibody against Human Protein C. Western blot validated at 1:1,000 dilution. Antigen affinity purified, supplied as liquid in PBS with glycerol and BSA. For research use only.
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Applications
Tested Applications and Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within Human Vitamin K-dependent protein C (aa 412–461) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% Glycerol, 0.2% BSA |
| Contains | 0.05% Sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2802695 |
Target Information
Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex. Activated Protein C contains a serine protease domain and degrades the activated forms of coagulation factors V and VIII. It is produced in the liver as a 62 kDa proenzyme, which is activated by thrombin bound to an endothelial receptor. The active enzyme (55 kDa) cleaves factors Va and VIIIa, inhibiting blood coagulation. Normal plasma concentrations are approximately 1–3 ng/mL for the active enzyme and ~3 µg/mL for the proenzyme. Mutations in the Protein C gene are associated with thrombophilia, neonatal purpura fulminans, and recurrent venous thrombosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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