Thermo Fisher Scientific OASL Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• Recommended positive control: U87-MG

Product Specifications

Product Specific Information

• Predicted reactivity: Chimpanzee (97%)
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis. 2-5As are produced by 2-5A synthetases (OASs), a highly conserved family of interferon-induced enzymes. The predicted 514-amino acid human p59OASL (2-5A synthetases-like) protein shares a conserved N-terminal domain with other OASs, while the C-terminal region contains two ubiquitin-like domains. p59OASL is expressed in most tissues, with highest levels in hematopoietic tissues, colon, and stomach.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.